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John Alan Goodwin, Ph.D Inorganic Chemistry Department
of Chemistry and Physics Coastal
SCI 209-A (843) 349-2295 jgoodwin@coastal.edu |
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Education
Courses currently taught at Coastal
General Chemistry
I and II (CHEM 111-112)
Advanced Inorganic
Chemistry (CHEM 411/411L)
Scholarly Activity
Polymer-supported Porphyrin Catalysts in Biomedical and
Green Chemistry Applications
Development and Assessment of Alternative Instructional
Materials in General Chemistry
Other
Professional Activities
Project
Kaleidoscope, Faculty for the 21st Century, Class of 1994
ACS Div Chem
Ed – Exams Institute
POGIL
– (Process Oriented Guided Inquiry Learning)
Publications (Student Authors in Bold).
Chemistry – The Science in
Context – Test Item File, Goodwin, J. A.; Gilbert, B. D. W. W.
Goodwin, J. A.; Kurtikyan, T. S.; Zheng, B.; Parmley,
D.; Howard, J.; Green, S.; Walsh, R.; Standard, J. Mardyukov,
A., Przybyla
D. E. “Variation of Oxo-transfer Reactivity of (Nitro) Cobalt
Picket Fence Porphyrin with Oxygen-Donating Ligands” Inorg. Chem. 2005, 44(7), 2215-2223.
Kurtikyan, T. S.; Mardyukov,
A. N.;Kazaryan, R. K.; Goodwin, J. A. “Interaction of NO2
gas with Sublimed Layers of meso-mono-4-pyridyl-tri-phenylporphyrinato cobalt(II). The Journal of Porphyrins and Phthalocyanines, 2003,
7, 775-779
Kurtikyan, T. S.; Mardyukov, A. N.; Goodwin, J. A. “Interaction of
Nitrogen Oxides with Sublimed Layers of (meso-tetraphenylporphyrinato)cobalt(II). IR evidences of Oxo Transfer from (Nitro)porphyrinatocobalt(III) to free
Nitric Oxide”, Inorg. Chem. 2003, 42 (25), 8489-8493.
Goodwin, J. A.; Smith, D. G. “Relationships of Student Learning
Preferences and Instructional Alternatives in General Chemistry” Academic Exchange Quarterly, Spring, 2003.
Goodwin, J.: Bailey, R.; Pennington, W.; Rasberry, R.; Green, T.; Shasho,
S.; Vongsavanh, M.; Echevarria,
V.; Tiedeken, J.; Brown, C.; Fromm, G.; Lyerly, S.; Watson, N.; Long, A.; De Nitto, N.
"Structural and Oxo-Transfer Reactivity Differences of Hexacoordinate and Pentacoordinate
(Nitro)(tetraphenylporphinato)cobalt(III)
Derivatives" Inorg. Chem., 2001, 40,
4217-4225.
Goodwin,
J. A.; Gilbert, B. D. “Cafeteria
Style Grading in General Chemistry” J.
Chem. Educ. 2001, 78, 490-494.
Frangione, M.; Port, J.; Baldiwala, M.;
Judd, A.; Galley, J.; DaVega, M.; Linna,
K.; Caron, L. Anderson, E.; Goodwin, J. “Thermochemistry
of Oxo Transfer from Coordinated Nitrite in the Dinitroiron(III) Picket
Fence Porphyrin Anion.” Inorg. Chem. 1997, 36, 1904-1911.
Recent Presentations (Student co-authors/presenters in
Bold)
“Nafion-Bound
Iron Porphyrins in Peroxynitrite Decomposition Catalysis.” Smith, Lindsay P.; Honsaker, Nicole D.;
Bradley, Nicole; Goodwin, John A., Abstracts, 57th Southeast/61st Southwest
Joint Regional Meeting of the American Chemical Society, Memphis, TN, United
States, November 1-4 (2005),
“Solution Phase Interactions of Cationic Iron Porphyrins and Nafion Oligomers.” Sides,
Mark D.;
Goodwin, John A..Abstracts,
57th Southeast/61st Southwest Joint Regional Meeting of the American Chemical
Society, Memphis, TN, United States, November 1-4 (2005
“Nafion-bound iron porphyrins in peroxynitrite decomposition
catalysis” Goodwin, John A.; Smith, Lindsay P. 230th
National Meeting of the ACS,
"A
POGIL Approach to Context-Rich General Chemistry" John Goodwin,
Tom Gilbert, and David Hanson (in
absentia), 2005 MADCP Meeting, Moravian College, Bethlehem, PA, June
5-7, 2005.
“Creation of an Honors General Chemistry Course for Well-Prepared
Science Students” John Goodwin, Scholarship of Teaching and Learning
Presentations –
“Tribulation
and National Identity:
“Peer-Led
Team Learning” Thomas Eberlein, John Goodwin and Emily Tarsis,
MID Project Workshop, North Carolina State University, Raleigh, NC, October
8-9, 2004
“Activation
of O2 by (Nitro)cobalt Porphyrins” John Goodwin, Graduate
Seminar, Department of Chemistry, University of South Carolina, Columbia, SC,
September 10, 2004.
“Five-coordinate
(nitro)cobalt porphyrins in heterogeneous oxidation catalysis” John A.
Goodwin, Tigran S. Kurtikyan, 228th ACS National Meeting,
“Semiempirical
and density functional studies of a series of (nitro)(porphyrinato)cobalt(III)
compounds with distal oxygen-bound ligands” John Goodwin, Jean M. Standard, Tigran S. Kurtikyan, David E. Przybyla,
Shaun Green . 228th ACS National Meeting,
“Immobilized (nitro)cobalt porphyrins
in oxo-transfer catalysis” John
A. Goodwin, Rosa B.
Walsh, Tigran S. Kurtikyan,
Deidra F. Parmley, and Arthur
N. Mardyukov. 227th ACS National
Meeting, Anaheim CA
“Peer Led Team Learning - A Pedagogical Model that Creates Good
"Chemistry" for Learning” John Goodwin and Emily
Tarsis, Project Kaleidoscope 2003 Minnesota Assembly -
Considering Pedagogies that Serve to Strengthen Student Learning University of St. Thomas, St. Paul, Minnesota October 10 – 12, 2003
Grant
Support
NSF: Collaborative Research: RUI: “Ionomer-Bound Metalloporphyrins as Heterogeneous Oxidation
Catalysts”, pending, $ 176,554
for CCU team and $173,746 to sub-award team at Georgia State College &
University, Rosalie Richards, PI of sub-award, pending.
NFSAT-CRDF
– US-Armenian Bilateral Grants Program, 2005, with Tigran
Kurtikyan.
“Identifying Reactive Intermediates in the Mechanism of Catalytic
Oxo-Transfer Reactions performed by metalloporphyrins” Funded $4000 for
US team of $30,000 total
NIH
INBRE,
2005-2006, with John Dawson, USC.
“Immobilized Iron Porphyrins in Catalytic Peroxynitrite
Decomposition”, Funded - P20 RR016461, $50,000 or 75,000 total.
Research
Corporation, 2005-2007,
“Immobilized Iron Porphyrins in Catalytic Peroxynitrite Decomposition”,
NFSAT-CRDF
– US-Armenian Bilateral Grants Program, 2003, with Tigran
Kurtikyan.
“Oxo-Transfer Reaction of Metalloporphyrin-Nitro Complexes”
Funded - $5000 for US team of $80,000 total
Research Synopsis
Metalloporphyrins
have a remarkably rich chemistry that ranges from biochemical active sites to
industrial catalysts. Some of the
biological roles, such as the iron centers in hemoglobin and the cytochromes as well as the photoreceptor in chlorophyll are
very well known for their ability to reversibly carry oxygen and to promote important
biochemical oxidation-reduction reactions.
Our research has focused on the catalytic oxidation-reduction reaction
chemistry of a few metalloporphyrins having iron and cobalt centers.
Some
cobalt porphyrins, CoP, are capable of transferring
an oxygen atom from a coordinated nitro ligand (CoP-NO2, as shown in
the figure) to a substrate, X, such as an alkene, to
make an oxidized substrate, XO.
(The figure shows the cobalt atom in green and the oxygen atoms in
red.) In doing so, they are reduced
to cobalt(II) nitrosyl
complexes (CoP-NO) that are able to react with
molecular oxygen to return to the nitro complex, CoP-NO2. Of course, in this state they may react
with more substrate if is available, and continue on in a catalytic cycle that
results in the overall reaction of:
O2
+ 2X = 2XO
We
found that the nitro complexes in solution that have only the porphyrin and
nitro ligand are much more reactive in this regard than porphyrins that have an
additional ligand in the position opposite the nitro ligand. In collaboration with Dr. Tigran Kurtikyan, we have
explored the adaptation of this solution-phase chemistry to the solid state to
better understand the details of the mechanism of oxygen atom transfer, and to
explore the possibility of using these as heterogeneous catalysts. That research involves sublimed thin
films of porphyrins that are somewhat fragile and easily dissolve in organic
solvents, so it is really a model system for studying the reactions of the
porphyrin in the solid state. The
current exploration of cationic porphyrins that are immobilized onto a
negatively charged polymer called Nafion®, is an
attempt to develop an oxidation catalyst that is robust enough for use with
moderately high temperatures, elevated pressures, and solutions that could
result in a usable oxidation catalyst.
Iron
porphyrins in solution are known to react catalytically with an important
biochemical oxidant called peroxynitrite that has the structural formula of
ONOO-. This oxidant
forms from the superoxide ion and nitric oxide in inflamed tissue and is
responsible for cellular damage.
The catalytic decomposition of peroxynitrite by iron porphyrins can take
two routes: if there is an abundance of an antioxidant such as ascorbic acid
(Vitamin C), the catalyst promotes the formation of nitrite ion by oxidizing
the ascorbic acid. In the absence
of antioxidants, as is usually the case in inflamed tissues, the catalyst
continues to decompose the peroxynitrite by rearranging it to the better known
and much more stable nitrate ion, NO3-.
We
are currently studying if it is possible to adapt this peroxynitrite
decomposition catalysis to the solid state, again by immobilizing cationic iron
porphyrins onto Nafion® polymer films.
With a system such as this it could be possible to prepare biomedical
implants with surfaces having the ability to decompose peroxynitrite and
therefore reduce the ill effects of inflammation in the tissues surrounding
them.
Techniques
include: anaerobic synthesis (Schlenk line and glove
box), UV-visible, FTIR, NMR, cyclic voltammetry, conventional and stopped-flow
kinetics, GC, IC, computational modeling with semi-empirical and density
functional models.
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